Our Product

lokelma sodium zirconium cyclosilicate

LOKELMA® (sodium zirconium cyclosilicate) 10g for oral

LOKELMA contains 400 mg of sodium in each 5 g dose. Watch for signs of swelling in your body especially if you limit sodium in your diet or are likely to have fluid retention in your body due to heart or kidney problems. Your doctor may tell you to reduce the sodium in your diet.

More

Patient Support

TERMS OF USE: Eligible commercially insured patients with a valid prescription for

More

Taking Lokelma

LOKELMA can cause swelling (edema) caused by fluid retention in your body (such as

More

What is Hyperkalemia

LOKELMA contains 400 mg of sodium in each 5 g dose. Watch for signs of swelling in your

More

Contact Us

IMPORTANT SAFETY INFORMATION FOR LOKELMA ® (sodium zirconium

More

Hyperkalemia Treatment LOKELMA® (sodium zirconium

IMPORTANT SAFETY INFORMATION FOR LOKELMA ® (sodium zirconium cyclosilicate) WARNINGS AND PRECAUTIONS: Gastrointestinal Adverse Events in Patients with Motility Disorders: Avoid LOKELMA in patients with severe constipation, bowel obstruction or impaction, including abnormal post-operative bowel motility disorders. LOKELMA has not been studied in patients with these

More

Lokelma (Sodium Zirconium Cyclosilicate): Uses, Dosage

May 12, 2020· Sodium zirconium cyclosilicate is a non-absorbed zirconium silicate that preferentially exchanges potassium for hydrogen and sodium. LOKELMA is a free flowing, odorless, insoluble white powder for oral suspension. It has a mean particle size of 20 µm and includes no more than 3% of particles with a diameter below 3 µm. Each 5 g of sodium

More

Lokelma (sodium zirconium cyclosilicate) Medical News Today

Aug 27, 2020· Lokelma is a brand-name prescription medication that’s used to treat hyperkalemia (high potassium levels) in adults.. The active drug in Lokelma is sodium zirconium cyclosilicate

More

Lokelma (sodium zirconium cyclosilicate) FDA Approval

May 20, 2018· Lokelma (sodium zirconium cyclosilicate) is a potassium binder indicated for the treatment of hyperkalemia in adults. Lokelma should not be used as an emergency treatment for life-threatening hyperkalemia because of its delayed onset of action. Dosage and Administration.

More

Sodium zirconium cyclosilicate (Lokelma) for hyperkalemia.

Dec 03, 2018· 1. Med Lett Drugs Ther. 2018 Dec 3;60(1561):197-199. Sodium zirconium cyclosilicate (Lokelma) for hyperkalemia. [No authors listed] PMID: 30653476

More

Mechanism of Action LOKELMA® (sodium zirconium

LOKELMA ® (sodium zirconium cyclosilicate) [prescribing information]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2020. 2. Stavros F, Yang A, Leon A, Nuttall M, Rasmussen HS. Characterization of structure and function of ZS-9, a K + selective ion trap. PloS One. 2014;9(12):e114686. 3. Kayexalate (sodium polystyrene sulfonate) [prescribing

More

LOKELMA PRESCRIBING INFORMATION

LOKELMA (sodium zirconium cyclosilicate) is a non-absorbed zirconium silicate that . preferentially captures potassium in exchange for hydrogen and sodium. In vitro, LOKELMA has a high affinity for potassium ions, even in the presence of other cations such as calcium and magnesium. LOKELMA increases fecal potassium excretion

More

Sodium Zirconium Cyclosilicate in Hyperkalemia NEJM

Nov 21, 2014· Sodium zirconium cyclosilicate (ZS-9) is a highly selective cation exchanger that entraps potassium in the intestinal tract in exchange for sodium and hydrogen (Fig. S1 in the Supplementary

More

Lokelma (sodium zirconium cyclosilicate) Medical News Today

Aug 27, 2020· Lokelma is a brand-name prescription medication that’s used to treat hyperkalemia (high potassium levels) in adults.. The active drug in Lokelma is sodium zirconium cyclosilicate, which

More

DailyMed LOKELMA- sodium zirconium cyclosilicate powder

Apr 24, 2020· LOKELMA (sodium zirconium cyclosilicate) is a non-absorbed zirconium silicate that preferentially captures potassium in exchange for hydrogen and sodium. In vitro, LOKELMA has a high affinity for potassium ions, even in the presence of other cations such as calcium and magnesium. LOKELMA

More

Sodium zirconium cyclosilicate Wikipedia

Sodium zirconium cyclosilicate (ZS-9), sold under the brand name Lokelma, is a medication used to treat high blood potassium. Onset of effects occurs in one to six hours. It is taken by mouth. Sodium zirconium cyclosilicate; Crystal structure of ZS-9. Blue spheres = oxygen atoms, red spheres = zirconium

More

Mechanism of Action LOKELMA® (sodium zirconium

LOKELMA ® (sodium zirconium cyclosilicate) [prescribing information]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2020. 2. Stavros F, Yang A, Leon A, Nuttall M, Rasmussen HS. Characterization of structure and function of ZS-9, a K + selective ion trap. PloS One. 2014;9(12):e114686. 3. Kayexalate (sodium

More

LOKELMA™ (sodium zirconium cyclosilicate) Prescribing

Find prescribing information for LOKELMA™ (sodium zirconium cyclosilicate) from AstraZeneca. Toggle navigation. Medical. If you are in the US and would like additional information regarding

More

Sodium zirconium cyclosilicate (Lokelma) for hyperkalemia.

Dec 03, 2018· 1. Med Lett Drugs Ther. 2018 Dec 3;60(1561):197-199. Sodium zirconium cyclosilicate (Lokelma) for hyperkalemia. [No authors listed] PMID: 30653476

More

Lokelma Side Effects: Common, Severe, Long Term Drugs

Jan 25, 2020· Note: This document contains side effect information about sodium zirconium cyclosilicate. Some of the dosage forms listed on this page may not apply to the brand name Lokelma.. For the Consumer. Applies to sodium zirconium cyclosilicate

More

Lokelma 10 g powder for oral suspension Summary of

May 14, 2020· Sodium zirconium cyclosilicate is a non-absorbed, non-polymer inorganic powder with a uniform micropore structure that preferentially captures potassium in exchange for hydrogen and sodium cations. Sodium zirconium cyclosilicate

More

Overview Sodium zirconium cyclosilicate for treating

Evidence-based recommendations on sodium zirconium cyclosilicate (Lokelma) for treating hyperkalaemia in adults.. Is this guidance up to date? Next review: 2022. Commercial arrangement. There is a simple discount patient access scheme for sodium zirconium cyclosilicate.

More

Sodium Zirconium Cyclosilicate in Hyperkalemia NEJM

Nov 21, 2014· Sodium zirconium cyclosilicate (ZS-9) is a highly selective cation exchanger that entraps potassium in the intestinal tract in exchange for sodium and hydrogen (Fig. S1 in the

More